Estimated readout windows: registry primary-completion date + 6-12 weeks. Windows already open are shown from "Now". Drug names link to ClinicalTrials.gov.
Phase 3 · ActiveModality: CAR T-cell therapy (fully human anti-CD19 autologous)
Aliases KYV-101, miv-cel
Target CD19
Partnerships NIH: exclusive worldwide license to anti-CD19 CAR patents for autoimmune disease (May 2021); Intellia: CRISPR patent license agreement covering CRISPR Product (co-co agreement)
Indications
Stiff person syndrome (SPS)(Phase 2)
Generalized myasthenia gravis (gMG)(Phase 3)
Progressive multiple sclerosis (PMS)(Phase 1)
Rheumatoid arthritis (RA)(Phase 1/2)
Lupus nephritis (LN)(Stage not disclosed)
Systemic sclerosis (SSc)(Stage not disclosed)
Catalysts
— Q3 2026
— Q4 2026
— Q3 2026
— mid-2027
— early 2027
Status note Lead program. SPS: registrational 26-patient Phase 2 KYSA-8 completed (positive primary analysis, AAN April 2026); pre-BLA meeting held Q2 2026 with FDA alignment on regulatory path; rolling BLA initiated (CMC module submitted July 2026, priority review sought under RMAT). gMG: KYSA-6 Phase 2 positive (Oct 2025 interim, AAN April 2026 longer-term follow-up); Phase 3 registrational trial advancing. RMAT and Orphan Drug designations for SPS and MG; EMA Orphan designation for MG.
KYV-102
Stage not disclosed · ActiveModality: whole blood rapid manufacturing process (Ingenui-T)
Target n/a
Status note IND accepted by FDA in January 2026.
KYV-201
Stage not disclosed · Active
Target CD19
Status note Named among other programs; no candidate details disclosed in excerpts.
Per-asset detail extracted from the 10-Q filed 2026-08-11. Fields the filing does not state are marked "not disclosed" rather than filled from other sources.
Sponsor-matched active trials from ClinicalTrials.gov (3 as sponsor, 5 as collaborator); "Sponsor" = company is the lead sponsor, "Collaborator" = company is a collaborator. The BP column flags big-pharma involvement as lead sponsor or collaborator (excluding the company itself). The Mgmt guide column shows what management guided for readout timing when a guided program matches the trial (hover for the quote, click for the source). Trial listings are not a company pipeline slide.
Institutional holder positions from 13F filings. Q/Q change is vs the prior quarter's filing; % of portfolio is the fund's own reported portfolio weight.
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